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2024

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development

Francesca W. van Tartwijk, Lucia C. S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A. H. Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter H. St George-Hyslop, et al.

The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 44(27) (2024) | Journal


Tensed axons are on fire

Kristian Franze

Proceedings of the National Academy of Sciences of the United States of America 121(5) (2024) | Journal | PDF



2023

Mechanics in the nervous system: From development to disease

Eva K. Pillai, Kristian Franze

Neuron 112(3) 342-361 (2023) | Journal | PDF


Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury

Alejandro Carnicer-Lombarte, Damiano G. Barone, Filip Wronowski, George G. Malliaras, James W. Fawcett, Kristian Franze

Biomaterials 303 (2023) | Journal | PDF


Brain tissue mechanics is governed by microscale relations of the tissue constituents

P. Sáez, C. Borau, N. Antonovaite, Kristian Franze

Biomaterials 301 (2023) | Journal | PDF


Plakoglobin is a mechanoresponsive regulator of naive pluripotency

Timo N. Kohler, Joachim De Jonghe, Anna L. Ellermann, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Antonia Weberling, Clara Munger, Katrin Fischer, et al.

Nature Communications 14(1) (2023) | Journal | PDF


Constriction imposed by basement membrane regulates developmental cell migration

Ester Molina López, Anna Kabanova, Alexander Winkel, Kristian Franze, Isabel M. Palacios, María D. Martín-Bermudo

PLoS biology 21(6) (2023) | Journal | PDF



2022

Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties

Gergerly Bertalan, Julia Becker, Heiko Tzschätzsch, Anna Morr, Helge Herthum, Mehrgan Shahryari, Ryan D. Greenhalgh, Jing Guo, Leif Schröder, et al.

Journal of the Mechanical Behavior of Biomedical Materials 138 (2022) | Journal | PDF


Retinal regions shape human and murine Müller cell proteome profile and functionality

Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, et al.

Glia 71(2) 391-414 (2022) | Journal | PDF


Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

Maximilian A. H. Jakobs, Assaf Zemel, Kristian Franze

eLife 11 (2022) | Journal | PDF


Cell surface fluctuations regulate early embryonic lineage sorting

Ayaka Yanagida, Elena Corujo-Simon, Christopher K. Revell, Preeti Sahu, Giuliano G. Stirparo, Irene M. Aspalter, Alex K. Winkel, Ruby Peters, Henry De Belly, et al.

Cell 185(7) (2022) | Journal | PDF


Cell surface fluctuations regulate early embryonic lineage sorting

Ayaka Yanagida, Elena Corujo-Simon, Christopher K. Revell, Preeti Sahu, Giuliano G. Stirparo, Irene M. Aspalter, Alex K. Winkel, Ruby Peters, Henry De Belly, et al.

Cell 185(5) 777-793.e20 (2022) | Journal | PDF


Effective cell membrane tension is independent of polyacrylamide substrate stiffness

Eva Kreysing, Jeffrey Mc Hugh, Sarah K. Foster, Kurt Andresen, Ryan D. Greenhalgh, Eva K. Pillai, Andrea Dimitracopoulos, Ulrich F. Keyser, Kristian Franze

PNAS nexus 2(1) (2022) | Journal | PDF


Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Damiano G. Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S. Hamilton, Malwina Prater, Alexandra L. Rutz, Ivan B. Dimov, George G. Malliaras, Stephanie P. Lacour, et al.

Proceedings of the National Academy of Sciences of the United States of America 119(12) (2022) | Journal | PDF


Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments

Julia Schaeffer, Isabell P. Weber, Amelia J. Thompson, Roger J. Keynes, Kristian Franze

Frontiers in Cell and Developmental Biology 10 (2022) | Journal | PDF



2021

StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells

Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, et al.

Nature Communications 12(1) (2021) | Journal | PDF


Vinculin is required for neuronal mechanosensing but not for axon outgrowth

De-Yao Wang, Cristina Melero, Ashwaq Albaraky, Paul Atherton, Karin A. Jansen, Andrea Dimitracopoulos, Federico Dajas-Bailador, Adam Reid, Kristian Franze, et al.

Experimental Cell Research 407(2) (2021) | Journal


Theory for Durotactic Axon Guidance

Hadrien Oliveri, Kristian Franze, Alain Goriely

Physical Review Letters 126(11) (2021) | Journal



2020

Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

Anna H. Lippert, Ivan B. Dimov, Alexander K. Winkel, Jane Humphrey, James McColl, Kevin Y. Chen, Ana M. Santos, Edward Jenkins, Kristian Franze, et al.

Biophysical Journal 120(1) 35-45 (2020) | Journal | PDF


Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle

Andrea Dimitracopoulos, Pragya Srivastava, Agathe Chaigne, Zaw Win, Roie Shlomovitz, Oscar M. Lancaster, Maël Le Berre, Matthieu Piel, Kristian Franze, et al.

Current biology: CB 30(18) 3687-3696.e4 (2020) | Journal | PDF


Towards brain-tissue-like biomaterials

Eneko Axpe, Gorka Orive, Kristian Franze, Eric A. Appel

Nature Communications 11(1) (2020) | Journal | PDF


Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

Rasha Rezk, Bill Zong Jia, Astrid Wendler, Ivan Dimov, Colin Watts, Athina E. Markaki, Kristian Franze, Alexandre J. Kabla

Neuro-Oncology Advances 2(1) (2020) | Journal | PDF


Integrating Chemistry and Mechanics: The Forces Driving Axon Growth

Kristian Franze

Annual Review of Cell and Developmental Biology 36 61-83 (2020) | Journal


Cortical cell stiffness is independent of substrate mechanics

Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze

Nature Materials 19(9) 1019-1025 (2020) | Journal


Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Maximilian A. H. Jakobs, Kristian Franze, Assaf Zemel

Biophysical Journal 118(8) 1914-1920 (2020) | Journal | PDF


Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Jacob Kjell, Judith Fischer-Sternjak, Amelia J. Thompson, Christian Friess, Matthew J. Sticco, Favio Salinas, Jürgen Cox, David C. Martinelli, Jovica Ninkovic, et al.

Cell Stem Cell 26(2) 277-293.e8 (2020) | Journal | PDF


The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale

Klara Kulenkampff, Anna H. Lippert, James McColl, Ana Mafalda Santos, Aleks Ponjavic, Edward Jenkins, Jane Humphrey, Alexander Winkel, Kristian Franze, et al.

Biophysical Journal 118(6) 1261-1269 (2020) | Journal | PDF



vor 2020

All-Optical Detection of Neuronal Membrane Depolarization in Live Cells Using Colloidal Quantum Dots

Mustafa Caglar, Raj Pandya, James Xiao, Sarah K. Foster, Giorgio Divitini, Richard Y. S. Chen, Neil C. Greenham, Kristian Franze, Akshay Rao, et al.

Nano Letters 19(12) 8539-8549 (2019) | Journal | PDF


Tissue stiffness at the human maternal-fetal interface

Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J. Brosens, Ashley Moffett, Andrew M. Sharkey, Kristian Franze, Graham J. Burton, et al.

Human Reproduction (Oxford, England) 34(10) 1999-2008 (2019) | Journal | PDF


Niche stiffness underlies the ageing of central nervous system progenitor cells

Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, et al.

Nature 573(7772) 130-134 (2019) | Journal


KymoButler, a deep learning software for automated kymograph analysis

Maximilian A. H. Jakobs, Andrea Dimitracopoulos, Kristian Franze

eLife 8 (2019) | Journal | PDF


F-actin dynamics regulates mammalian organ growth and cell fate maintenance

Arianna Pocaterra, Giulia Santinon, Patrizia Romani, Irene Brian, Andrea Dimitracopoulos, Andrea Ghisleni, Alejandro Carnicer-Lombarte, Mattia Forcato, Paola Braghetta, et al.

Journal of Hepatology 71(1) 130-142 (2019) | Journal


Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

Amelia J. Thompson, Eva K. Pillai, Ivan B. Dimov, Sarah K. Foster, Christine E. Holt, Kristian Franze

eLife 8 (2019) | Journal | PDF


Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Jean-Michel Cioni, Julie Qiaojin Lin, Anne V. Holtermann, Max Koppers, Maximilian A. H. Jakobs, Afnan Azizi, Benita Turner-Bridger, Toshiaki Shigeoka, Kristian Franze, et al.

Cell 176(1-2) 56-72.e15 (2019) | Journal | PDF


Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons

Benita Turner-Bridger, Maximillian Jakobs, Leila Muresan, Hovy Ho-Wai Wong, Kristian Franze, William A. Harris, Christine E. Holt

Proceedings of the National Academy of Sciences of the United States of America 115(41) E9697-E9706 (2018) | Journal | PDF


Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, et al.

Nature Communications 9(1) (2018) | Journal | PDF


Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor

Nature 554(7693) 523-527 (2018) | Journal


The role of cell body density in ruminant retina mechanics assessed by atomic force and Brillouin microscopy

Isabell P. Weber, Seok Hyun Yun, Giuliano Scarcelli, Kristian Franze

Physical Biology 14(6) (2017) | Journal | PDF


Effect of vital dyes on human corneal endothelium and elasticity of Descemet's membrane

Isabell P. Weber, Mrinal Rana, Peter B. M. Thomas, Ivan B. Dimov, Kristian Franze, Madhavan S. Rajan

PloS One 12(9) (2017) | Journal | PDF


Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila

María C. Díaz de la Loza, Alfonsa Díaz-Torres, Federico Zurita, Alicia E. Rosales-Nieves, Emad Moeendarbary, Kristian Franze, María D. Martín-Bermudo, Acaimo González-Reyes

Cell Reports 20(1) 211-223 (2017) | Journal | PDF


Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy

Nils M. Kronenberg, Philipp Liehm, Anja Steude, Johanna A. Knipper, Jessica G. Borger, Giuliano Scarcelli, Kristian Franze, Simon J. Powis, Malte C. Gather

Nature Cell Biology 19(7) 864-872 (2017) | Journal


The soft mechanical signature of glial scars in the central nervous system

Emad Moeendarbary, Isabell P. Weber, Graham K. Sheridan, David E. Koser, Sara Soleman, Barbara Haenzi, Elizabeth J. Bradbury, James Fawcett, Kristian Franze

Nature Communications 8 (2017) | Journal | PDF


Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, et al.

Nature 537(7621) 544-547 (2016) | Journal


ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

John R. Pearson, Federico Zurita, Laura Tomás-Gallardo, Alfonsa Díaz-Torres, María Del Carmen Díaz de la Loza, Kristian Franze, María D. Martín-Bermudo, Acaimo González-Reyes

PLoS genetics 12(1) (2016) | Journal | PDF


Brain tissue stiffness is a sensitive marker for acidosis

Kathrin Holtzmann, Helene O. B. Gautier, Andreas F. Christ, Jochen Guck, Ragnhildur Thora Karadottir, Kristian Franze

JOURNAL OF NEUROSCIENCE METHODS 271 50-54 (2016) | Journal


Force Generation by Molecular-Motor-Powered Microtubule Bundles; Implications for Neuronal Polarization and Growth

Maximilian Jakobs, Kristian Franze, Assaf Zemel

Frontiers in Cellular Neuroscience 9 (2015) | Journal | PDF


Müller glia provide essential tensile strength to the developing retina

Ryan B. MacDonald, Owen Randlett, Julia Oswald, Takeshi Yoshimatsu, Kristian Franze, William A. Harris

The Journal of Cell Biology 210(7) 1075-1083 (2015) | Journal | PDF


Microglia mechanics: immune activation alters traction forces and durotaxis

Lars Bollmann, David E. Koser, Rajesh Shahapure, Hélène O. B. Gautier, Gerhard A. Holzapfel, Giuliano Scarcelli, Malte C. Gather, Elke Ulbricht, Kristian Franze

Frontiers in Cellular Neuroscience 9 (2015) | Journal | PDF


Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo

Ivan Bedzhov, Monika Bialecka, Agata Zielinska, Joanna Kosalka, Francesco Antonica, Amelia J. Thompson, Kristian Franze, Magdalena Zernicka-Goetz

Cell Research 25(12) 1368-1371 (2015) | Journal | PDF


CNS cell distribution and axon orientation determine local spinal cord mechanical properties

David E. Koser, Emad Moeendarbary, Janina Hanne, Stefanie Kuerten, Kristian Franze

Biophysical Journal 108(9) 2137-2147 (2015) | Journal | PDF


Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids

Alex S. Randall, Che-Hsiung Liu, Brian Chu, Qifeng Zhang, Sidharta A. Dongre, Mikko Juusola, Kristian Franze, Michael J. O. Wakelam, Roger C. Hardie

The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 35(6) 2731-2746 (2015) | Journal | PDF


Atomic force microscopy-based force measurements on animal cells and tissues

Hélène O. B. Gautier, Amelia J. Thompson, Sarra Achouri, David E. Koser, Kathrin Holtzmann, Emad Moeendarbary, Kristian Franze

Methods in Cell Biology 125 211-235 (2015) | Journal


Auxetic nuclei in embryonic stem cells exiting pluripotency

Stefano Pagliara, Kristian Franze, Crystal R. McClain, George Wylde, Cynthia L. Fisher, Robin J. M. Franklin, Alexandre J. Kabla, Ulrich F. Keyser, Kevin J. Chalut

Nature Materials 13(6) 638-644 (2014) | Journal


The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

Pouria Moshayedi, Gilbert Ng, Jessica C. F. Kwok, Giles S. H. Yeo, Clare E. Bryant, James W. Fawcett, Kristian Franze, Jochen Guck

BIOMATERIALS 35(13) 3919-3925 (2014) | Journal | PDF


Mechanics in Neuronal Development and Repair

Kristian Franze, Paul A. Janmey, Jochen Guck

Annual Review of Biomedical Engineering 15(1) 227-251 (2013) | Journal


Photomechanical responses in Drosophila photoreceptors

Roger C. Hardie, Kristian Franze

Science (New York, N.Y.) 338(6104) 260-263 (2012) | Journal


Complex stiffness gradient substrates for studying mechanotactic cell migration

Cheng-Hwa R. Kuo, Jian Xian, James D. Brenton, Kristian Franze, Easan Sivaniah

Advanced Materials (Deerfield Beach, Fla.) 24(45) 6059-6064 (2012) | Journal


Photonic Crystal Light Collectors in Fish Retina Improve Vision in Turbid Water

Moritz Kreysing, Roland Pusch, Dorothee Haverkate, Meik Landsberger, Jacob Engelmann, Janina Ruiter, Carlos Mora-Ferrer, Elke Ulbricht, Jens Grosche, et al.

SCIENCE 336(6089) 1700-1703 (2012) | Journal


Reversible switching between superhydrophobic states on a hierarchically structured surface

Tuukka Verho, Juuso T. Korhonen, Lauri Sainiemi, Ville Jokinen, Chris Bower, Kristian Franze, Sami Franssila, Piers Andrew, Olli Ikkala, et al.

Proceedings of the National Academy of Sciences of the United States of America 109(26) 10210-10213 (2012) | Journal | PDF


Atomic force microscopy and its contribution to understanding the development of the nervous system

Kristian Franze

Current Opinion in Genetics & Development 21(5) 530-537 (2011) | Journal


Growth cones as soft and weak force generators

Timo Betz, Daniel Koch, Yun-Bi Lu, Kristian Franze, Josef A. Käs

Proceedings of the National Academy of Sciences of the United States of America 108(33) 13420-13425 (2011) | Journal | PDF


Metastable underwater superhydrophobicity

Rosa Poetes, Kathrin Holtzmann, Kristian Franze, Ullrich Steiner

Physical Review Letters 105(16) (2010) | Journal


Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

Pouria Moshayedi, Luciano da F. Costa, Andreas Christ, Stephanie P. Lacour, James Fawcett, Jochen Guck, Kristian Franze

JOURNAL OF PHYSICS-CONDENSED MATTER 22(19) 194114 (2010) | Journal


Retinal glial (Müller ) cells: sensing and responding to tissue stretch

Niclas Lindqvist, Qing Liu, Joachim Zajadacz, Kristian Franze, Andreas Reichenbach

Investigative Ophthalmology & Visual Science 51(3) 1683-1690 (2010) | Journal | PDF


Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy

Andreas F. Christ, Kristian Franze, Helene Gautier, Pouria Moshayedi, James Fawcett, Robin J. M. Franklin, Ragnhildur T. Karadottir, Jochen Guck

JOURNAL OF BIOMECHANICS 43(15) 2986-2992 (2010) | Journal


Neurite branch retraction is caused by a threshold-dependent mechanical impact

Kristian Franze, Jens Gerdelmann, Michael Weick, Timo Betz, Steve Pawlizak, Melike Lakadamyali, Johannes Bayer, Katja Rillich, Michael Gögler, et al.

Biophysical Journal 97(7) 1883-1890 (2009) | Journal | PDF


Optical neuronal guidance

Allen Ehrlicher, Timo Betz, Björn Stuhrmann, Michael Gögler, Daniel Koch, Kristian Franze, Yunbi Lu, Josef Käs

Methods in Cell Biology 83 495-520 (2007) | Journal


Müller cells are living optical fibers in the vertebrate retina

Kristian Franze, Jens Grosche, Serguei N. Skatchkov, Stefan Schinkinger, Christian Foja, Detlev Schlid, Ortrud Uckermann, Kort Travis, Andreas Reichenbach, et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104(20) 8287-8292 (2007) | Journal | PDF


Viscoelastic properties of individual glial cells and neurons in the CNS

Yun-Bi Lu, Kristian Franze, Gerald Seifert, Christian Steinhaeuser, Frank Kirchhoff, Hartwig Wolburg, Jochen Guck, Paul Janmey, Er-Qing Wei, et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103(47) 17759-17764 (2006) | Journal | PDF


GABA<sub>A</sub> receptors in Müller glial cells of the human retina

Bernd Biedermann, Andreas Bringmann, Kristian Franze, Frank Faude, Peter Wiedemann, Andreas Reichenbach

Glia 46(3) 302-310 (2004) | Journal


Selective staining by vital dyes of Müller glial cells in retinal wholemounts

Ortrud Uckermann, Ianors Iandiev, Mike Francke, Kristian Franze, Jens Grosche, Sebastian Wolf, Leon Kohen, Peter Wiedemann, Andreas Reichenbach, et al.

Glia 45(1) 59-66 (2003) | Journal


Publikationen

Kontakt

Friedrich-Alexander-Universität Erlangen-Nürnberg
Institute of Medical Physics
Henkestr. 91
91052 Erlangen

Tel: +49 (0)9131 85-22310
E-Mail: kristian.franze@fau.de

 

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